How BIRN is organized

• BIRN Executive Committee
• Key Personnel
• Participating Institutions

What BIRN offers

• BIRN CC Tools Primer
• fBIRN Tools Primer
• mBIRN Tools Primer
• Mouse BIRN Tools Primer
• BIRN Data Repository

Who uses BIRN

• BIRN Coordinating Center
• Function BIRN
• Morphometry BIRN
• Mouse BIRN

Affiliated Sites

• NCRR
• NIH-CIT
• NDAR
• NA-MIC
• UK e-Science

BIRN Glossary

Copyright

EAE Mouse model of Multiple Sclerosis

Overview

This document describes multiple datasets for an Experimental Autoimmune Encephalitis (EAE) mouse model of Multiple Sclerosis. These datasets were collected by collaborators at Caltech BIC, Duke CIVM, and UCLA LONI to examine a mouse model of multiple sclerosis.

Figure 1. Minimum deformation atlas of 76 isotropic diffusion weighted images (iDWI) in MBAT.

Description

Mouse BIRN and our collaborators have used the EAE model of MS to visualize disease induced structural changes in the brain. Continuing MR and histology experiments have focused on identifying the pathological underpinnings of grey matter atrophy. MR studies with the Caltech and Duke sites, have demonstrated that this model shows increased grey matter atrophy in the cerebellum and a profound affect of disease upon the Purkinje neurons of the cerebellum. Three different types of data are available via this project:

• Magnetic Resonance Microscopy (MRM) data collected by Dr. Russ Jacob's group at Beckman Institute, California Institute of Technology
• Magnetic Resonance Histology (MRH) data collected by Dr. G. Allan Johnson's group at CIVM, Duke University Medical Center
• Glial fibrillary acidic protein (GFAP) Immunohistology collected by Dr. Allan MacKenzie-Graham and others in his group at LONI, University of California, Los Angeles

Usage

This dataset can be viewed using the Mouse BIRN Atlasing Tool (MBAT). See the respective manual for the program.

Contributors

Allan MacKenzie-Graham1, Matthew R. Tinsley 2, Kaanan P. Shah1, Cynthia Aguilar1, Lauren V. Strickland1, Jyl Boline1, Melanie Martin3, Laurie Morales4 , David W. Shattuck1, Russell E. Jacobs5, Rhonda R. Voskuhl4, and Arthur W. Toga1

1. Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles.
2. Department of Psychology, University of California, Los Angeles.
3. Department of Physics, University of Winnipeg.
4. Multiple Sclerosis Program, Department of Neurology, University of California, Los Angeles.
5. Beckman Institute, California Institute of Technology.

References

MacKenzie-Graham, A., Tinsley, M.R., Shah, K.P., Aguilar, C., Strickland, L.V., Boline, J., Martin, M., Morales, L., Shattuck, D.W., Jacobs, R.E., Voskuhl, R.R., and Toga, A.W. (2006) Cerebellar Cortical Atrophy in Experimental Autoimmune Encephalomyelitis. Neuroimage, 32(3):1016-23.

Acknowledgement

This work was made possible by Grant Number U24 RR021760 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of NCRR or NIH.