Mouse Tissue Lineage Hierarchy
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Overview
This document describes a preliminary tissue lineage hierarchy from the Caltech µMRI Atlas of Mouse Development in collaboration with the Edinburgh Mouse Atlas Project (EMAP).
Short Description
An aspect of embryonic development is the process of cell and tissue differentiation. Currently, embryonic atlases capture a static geometric and spatial representation of the developing organism. As part of our Atlas project, we are tying anatomy for each stage of development with the developmental history for each anatomical component. The lineage hierarchy (ontology) being developed utilizes the EMAP IDs for anatomical components to leverage the wealth of gene expression data available through the MGI and EMAGE. Through this ontology, the gene expression history of tissues can be accessed. This incarnation of the ontology is an exercise in the construction of such a hierarchy.
Figure
Hyperbolic tree graph view of tissue lineage of TS 26 (18 day post coitus ) mouse fetus. The graph was rendered using Braintree module of SHIVA (www.loni.ucla.edu) translated from Gene Ontology formatted data. The ontology was constructed with COBrA (http://www.xspan.org/cobra/cobra.html).
Categories and Keywords
Mouse Development, lineage ontology, atlas
References for the Software
This ontology can be viewed using SHIVA (Laboratory of Neuro Imaging, UCLA)
This ontology was constructued using COBrA (A Concept Ontology Browser for Anatomy Version 1.01 Roman Korf, Stuart Aitken 2003). http://www.xspan.org/cobra/cobra.html
Contributors/Authors
Seth Ruffins, California Institute of Technology, Pasadena
Technical Contacts
Seth Ruffins, sruffins@caltech.edu
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